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The positive regulation of pro-inflammatory macrophage activity appears to be dependent on activation of STAT1, whereas the increased anti-inflammatory activation is driven by ERα-mediated phosphorylation and activation of STAT3 and interference with p65 subunit binding to the NF-κB complex (158–161)

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Although healthy diets such as the Mediterranean diet show promise in reducing the risk of ADHD, evidence supporting non-pharmacological treatments remains limited and requires further investigation