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Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cells in concert with a variety of tumour-associated stromal cells and their bioactive products, which encompass cytokines and growth factors, the extracellular matrix and secreted microvesicles

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Conversely, treatment of αTC1-6 cells with the STAT3 inhibitor S3I-201 markedly decreased amino acid-induced STAT3 phosphorylation and VGF levels but not proglucagon levels (Fig