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Mechanism of Action: α2 adrenoreceptor agonist Peripheral : α2 agonists can directly cause arterial vasoconstriction , which can cause an initial phase of hypertension , before centrally mediated effects predominate, resulting in reduced sympathetic outflow from the CNS, which results in both bradycardia and hypotension (Malayala et al, 2022

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Robust desensitization generally precedes endocytosis and can occur when endocytosis is absent or prevented (Johnson et al., 2005