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While FOXO4 can influence mitochondrial function indirectly through its regulatory effects on cellular processes, it does not directly target mitochondria like the other mitochondria-targeted peptides listed above

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29 Serious adverse events (SAEs) for participants treated with tirzepatide were reported with a frequency of 5–7% in participants without T2D (SURMOUNT-1) and 6–9% in participants with T2D (SURMOUNT-2 trial)