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Radiologically, MMNSTs typically show T1 hyperintensity and T2 hypointensity on MRI due to intratumoral melanin ( For metastatic MMNST, ifosfamide plus doxorubicin is the most reported chemotherapy regimen, while fotemustine has shown partial remission in one case ( Anlotinib’s efficacy in MPNSTs was recently suggested by Chen ( The prolonged disease control observed in this patient is likely attributable to the synergistic interplay among anlotinib’s multifaceted antitumor mechanisms