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Hemoglobin concentrations (mmol/L) of ARA 290 patients compared with placebo were 8.9 ± 0.21 (standard error of the mean [SEM]) versus 8.6 ± 0.26 at baseline and 8.7 ± 0.19 versus 8.7 ± 0.34 at the end of dosing on wk 4

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Pawlak and others reviewed studies of B12 deficiency among vegetarians and vegans using serum B12 (Pawlak, 2014) as well as methylmalonic acid and holotranscobalamin (Pawlak, 2013)