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In an eight-week, randomized, placebo-controlled trial that included 46 menopausal women being treated with citalopram (Celexa), the addition of vitex (equivalent of 1,000 mg dried vitex berry daily) plus black cumin ( Nigella sativa , 500 mg ground seeds daily) to treatment resulted in greater improvements in hot flashes and physical and psychosocial functioning compared with placebo