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Drought and salt stress tolerance of an Arabidopsis glutathione S -transferase U17 knockout mutant are attributed to the combined effect of glutathione and abscisic acid

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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time