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This reaction is catalysed by glutathione reductase (GR) and requires NADPH, a reductive biosynthesis coenzyme [42]

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FOXO4-DRI is a synthetic senolytic peptide developed to selectively target and eliminate senescent cells, often referred to as "zombie cells." These dysfunctional cells accumulate with aging and are associated with chronic inflammation, tissue degeneration, and age-related decline