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The FDA’s decision was based on the Phase III APPLAUSE-IgAN study, in which treatment with Fabhalta cut proteinuria by 44% through nine months of follow-up, while placebo comparators saw only a 9% reduction in proteinuria

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Treatment strategies can be categorized based on their targets, including the disruption of excitotoxicity, management of oxidative stress and mitochondrial dysfunction, treatment of inflammation and abnormal immune responses, modulation of glial cells, and the use of gene and stem cell therapies