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Pharmaceutical GH (recombinant somatropin) does have strong clinical data for GH-deficient adults, including lean mass increases averaging 2-3 kg over six months in trials like Jorgensen et al

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This not only enhances the cells’ responsiveness to IL-23 but also leads to the upregulation of several inflammatory genes like IL-17A, IL-17F, and IL-18R1 within Th17 cells