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Some research suggests DSIP may enhance GABAergic inhibitory neurotransmission, which would be consistent with its sleep-promoting and anxiolytic properties, as GABA is the principal inhibitory neurotransmitter in the central nervous system and many sleep medications work by enhancing GABAergic function

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Moreover, multiple studies have shown that oral NAD+ is poorly absorbed and does not significantly raise NAD+ levels in the plasma or tissues[9]