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One such specialized group of enzymes called Glutathione-S-Transferase (GST) attach glutathione to the byproducts of Phase 1 detoxification and neutralizes their toxic potential while simultaneously making these toxic substances more water-soluble and ready to be eliminated

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Therefore, addressing these challenges requires a multifaceted approach that integrates the precise characterization of CSC subpopulations, targeted disruption of their metabolic flexibility, and the identification of selective CSC markers for improved therapeutic efficacy