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For example, in HCC patients, gut microbe-associated feature scores showed cancer-type-specific genomic alterations and immune microenvironment feature associations, and can serve as potential clinical biomarkers for immunotherapy responsiveness and recurrence in multiple malignancies, providing a comprehensive framework for quantifying microbe-driven transcriptional activity and its clinical significance in cancer

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In situ or peripheral neuroinflammation, including glial cell activity [7,8], and pro-inflammatory cytokines [9], has been observed in post-mortem brain samples from PD patients, which might contribute to the cascade of events that lead to neurodegeneration