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The gut produces these compounds in response to various signals, including the presence of beneficial bacteria, the integrity of the intestinal lining, and inflammatory status

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The An 2019 clinical trial in Annals of Dermatology tested a crosslinked hyaluronic acid microneedle patch loaded with sh-Oligopeptide-1 and Acetyl Hexapeptide-8 against vehicle control in Korean women with peri-orbital wrinkles, and found significant reductions in wrinkle depth and improvements in skin elasticity over 8 weeks [37]

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