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This is due, on the one hand, to the fact that patients with diabetes mellitus have high levels of furin, a protease involved in cleaving the S1 and S2 domains of the virus spike protein, which facilitates the entry of the virus into the cell (Fernandez et al., 2018)

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Furthermore, Dihexa decreased the activation of astrocytes and microglia, markedly reduced levels of the pro-inflammatory cytokines IL-1β and TNF-α and increased the levels of the anti-inflammatory cytokine IL-10