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LNK is mainly expressed in hematopoietic cells and is known to be important for regulating a number of signaling pathways mediated by the TPOR (MPL), erythropoietin receptor (EPOR), stem cell factor receptor (KIT and SCFR), macrophage colony-stimulating factor receptor (CSF1R and C-FMS), and platelet-derived growth factor receptor (PDGFRB)