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11 However, another selective Y5-receptor antagonist (S-2367) (Shionogi USA, Inc.) induced a mean placebo-adjusted weight loss of 3.0% baseline weight (p 50% of the subjects receiving 600 µg PYY (3–36) withdrew from the study due to nausea and vomiting, 26 indicating that further improvements to the formulation and/or delivery method of PYY remain