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In addition, berberine can properly restore the levels of 3-nitrotyrosine (3-NT), COX 2, glial fibrillary acidic protein (GFAP), and sirtuin 1 in the hippocampus (Sadraie et al., 2019)

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This study describes a novel biochemical mechanism by which glutathione deficiency causes epigenetic impairment of vitamin D metabolism gene in the liver and its contribution to reduced circulating levels of 25(OH)VD 3 in HFD-fed obese mice