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10.1016/j.clnu.2016.06.017 34 ChenW.SchilperoortM.CaoY.ShiJ.TabasI.TaoW

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Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes