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[6] Vegans—people who choose to not consume any animal-sourced foods—are at risk because plant-sourced foods do not contain the vitamin in sufficient amounts to prevent vitamin deficiency

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At therapeutic doses it is safe for most people, but acetaminophen metabolism uses glutathione directly, and chronic high dose use is the leading cause of acute liver failure in the United States precisely because it exhausts hepatic glutathione (PubMed PMID: 26041729)