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[DOI] [PubMed] [Google Scholar] 57.Petukhova L., Patel A.V., Rigo R.K., Bian L., Verbitsky M., Sanna-Cherchi S., Erjavec S.O., Abdelaziz A.R., Cerise J.E., Jabbari A., et al

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In turn, peroxynitrite oxidizes and destabilizes eNOS to produce additional superoxide.[33] BH4 is highly sensitive to oxidation and upper oxide leads to BH4 oxidation, which promotes eNOS uncoupling and further ROS production