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Freedman and colleagues found a mononuclear 1:1 complex at neutral pH and identified histidine imidazole nitrogen within the Cu(II) coordination environment

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However, in one study of six hypertensive subjects exhibiting fairly good blood pressure control (average of 139/93 mmHg) with the ACE inhibitor lisinopril, the addition of NAC, 1.2 g/day for one week, caused a significant decrease in both the systolic and diastolic blood pressures (38)