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In this context, studies have shown that the SSRIs fluoxetine and paroxetine lessened the loss of nigral dopaminergic neurons caused by lipopolyscaccharide or by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Chung et al., 2010[10][11]), while escitalopram protected against ischemia-induced neuronal death in the gerbil hippocampal CA1 region after transient cerebral ischemia (Lee et al., 2011[39])

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