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PMID: 19238460 Prescription Information: rxlist.com (cocaine / topical) rxlist.com (Goprelto ®) topical cocaine nasal spray Keywords Imipramine Trade Name: Tofranil ® Drug Class: TCA antidepressant (tricyclic amine) Mechanism of Action: Blocks presynaptic reuptake transporters for norepinephrine & serotonin (NET & SERT) on nerve endings (therapeutic effects) Antimuscarinic (contributes to side effects) Antihistamine (contributes to side effects) Alpha receptor blocking properties (contributes to side effects) Several weeks to months are required for antidepressant effects to appear (or be significantly greater than a placebo), although its direct effects (e.g