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avoiding high-fat foods ✅ Temporary dose reduction – Stepping back to previous dose if symptoms severe ✅ Antiemetic support – When appropriate under medical supervision Contraindications and Precautions Certain populations should exercise particular caution with cagrilintide: 🚫 Personal or family history of medullary thyroid carcinoma 🚫 Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) 🚫 Severe gastrointestinal disease 🚫 History of pancreatitis 🚫 Pregnancy or breastfeeding These contraindications overlap significantly with those for GLP-1 receptor agonists like tirzepatide, making combination approaches even more critical to approach cautiously

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Following a 1-week acclimatization period, the mice were randomly assigned to four groups (n = 8): Control, DSS, DSS + 5-ASA, and DSS + GHK-Cu

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